Integration problem

[Bastian Hirn-Derksen]

Dear all,

 

I hope someone of you can help me with a problem in GNU McSim I obtain, when I wont to calibrate my model via MCMC. When I start MCMC calibration Im getting the following error message :

Doing 10000 Metropolis within Gibbs simulations

lsodes-- at start of problem, too much accuracy   

         requested for precision of machine..  see tolsf (=r1)

 in above message, r1=      1.#QNAN00000000

Warning: DoOneExperiment failed

 

Im aware that there must be an issue with the ode solver and the integration of the data, but Internet research did not provide any solution. I also tried to set the atol and rtol value to zero for having absolute error tolerance but this also did not work and occured in this error message:

Doing 10000 Metropolis within Gibbs simulations

lsodes-- at start of problem, too much accuracy  

         requested for precision of machine..  see tolsf (=r1)

 in above message, r1=      1.#QNAN00000000

Warning: DoOneExperiment failed

 

I hope you can help me with this problem. Calibration of the model is essential for my work and therefore I have to find a solution of the problem.

 

With kind regards,

--

Bastian Hirn-Derksen

Apotheker

Westfälische Wilhelms-Universität Münster Institut für Pharmazeutische und Medizinische Chemie

- Klinische Pharmazie -

Raum A 120.202

Corrensstraße 48

48149 Münster, Germany

Phone: +49 251 83 33364

Fax.: +49 251 83 32144

E-mail: b_hirn01@uni-muenster.de