[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
01/03: gnu: Add r-scgate.
From: |
guix-commits |
Subject: |
01/03: gnu: Add r-scgate. |
Date: |
Tue, 2 Jan 2024 04:21:32 -0500 (EST) |
rekado pushed a commit to branch master
in repository guix.
commit 7593364d70fa81b761c1d9b0269510b21364c6fa
Author: Mădălin Ionel Patrașcu <madalinionel.patrascu@mdc-berlin.de>
AuthorDate: Wed Dec 27 11:02:34 2023 +0100
gnu: Add r-scgate.
* gnu/packages/bioconductor.scm (r-scgate): New variable.
Change-Id: I441bbea5a68882f5f619dea72abdf84619c9d02f
---
gnu/packages/bioconductor.scm | 43 +++++++++++++++++++++++++++++++++++++++++++
1 file changed, 43 insertions(+)
diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index 316aa20026..427fa4ebfe 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -10314,6 +10314,49 @@ includes methods formerly found in the scran package,
and the new fast and
comprehensive scDblFinder method.")
(license license:gpl3)))
+;; This is a CRAN package, but it depends on packages from Bioconductor.
+(define-public r-scgate
+ (package
+ (name "r-scgate")
+ (version "1.6.0")
+ (source
+ (origin
+ (method url-fetch)
+ (uri (cran-uri "scGate" version))
+ (sha256
+ (base32 "0h12d36zjc6fvxbhkxrzbpvw49z9fgyn1jc941q70ajw1yqi2hhh"))))
+ (properties `((upstream-name . "scGate")))
+ (build-system r-build-system)
+ (propagated-inputs
+ (list r-biocparallel
+ r-dplyr
+ r-ggplot2
+ r-ggridges
+ r-patchwork
+ r-reshape2
+ r-seurat
+ r-ucell))
+ (native-inputs (list r-knitr))
+ (home-page "https://github.com/carmonalab/scGate")
+ (synopsis
+ "Marker-based cell type purification for single-cell sequencing data")
+ (description
+ "This package provides a method to purify a cell type or cell population
+of interest from heterogeneous datasets. scGate package automatizes
+marker-based purification of specific cell populations, without requiring
+training data or reference gene expression profiles. scGate takes as input a
+gene expression matrix stored in a Seurat object and a @acronym{GM, gating
+model}, consisting of a set of marker genes that define the cell population of
+interest. It evaluates the strength of signature marker expression in each
+cell using the rank-based method UCell, and then performs @acronym{kNN,
+k-nearest neighbor} smoothing by calculating the mean UCell score across
+neighboring cells. kNN-smoothing aims at compensating for the large degree of
+sparsity in scRNAseq data. Finally, a universal threshold over kNN-smoothed
+signature scores is applied in binary decision trees generated from the
+user-provided gating model, to annotate cells as either “pure” or “impure”,
+with respect to the cell population of interest.")
+ (license license:gpl3)))
+
;; This is a CRAN package, but it depends on packages from Bioconductor.
(define-public r-scistreer
(package