I've been using duplicity-0.6.08b (Python 2.4.3, boto-1.9b, GnuPG 1.4.5) successfully for quite some time, but decided it was time to upgrade. (Famous last words.)
I installed duplicity-0.6.25 and boto-2.1.1 and after resolving some new dependencies, I got the following when I tried to run a backup: